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观察了小鼠暴露在不同海拔梯度下脑含水量改变及其与脑水肿的关系。实验结果表明，小鼠由低海拔区快速进入高海拔区后脑组织的湿干比值和含水量均有增高（Ｐ＜００１），以进入高海拔区后的第７ｄ为最高峰。组织学观察表明，此时脑神经细胞肿胀，胞浆内有空泡变性，胶质细胞和微血管周围有明显空晕。以上结果揭示，由低海拔区快速进入高海拔区后可致脑水肿形成。
The changes of brain water content and its relationship with cerebral edema in mice exposed to different altitudes were observed. The experimental results showed that the wet-dry ratio and water content of brain tissue of mice increased rapidly (P <001) after entering the high altitude region from low altitude region, and reached the peak on the 7th day after entering the high altitude region. Histological observation showed that brain cells were swollen at this time, with vacuolar degeneration in the cytoplasm, obvious empty halo around glial cells and microvessels. The above results revealed that rapid development of brain edema by low-altitude zone into the high-altitude area.