人的血型是由遗传物质决定的,受控于第9号染色体长臂的血型基因,一般终身不变。血型变异在临床上极为罕见,国内仅有少数报道〔1〕。我们在临床工作中遇到2例白血病患者化疗后发生血型变异,现报告如下。1病例资料例1,男,28岁,于2011年4月无明显诱因出现乏力、头晕、恶心、食欲下降、全身不适症状,伴有高热,最高体温达39.5℃,口腔血疱,牙龈出血。血 Human blood type is determined by the genetic material, controlled by the long arm of chromosome 9 blood group genes, generally unchanged for the rest of the world. Blood type variation is extremely rare in clinical practice, only a few reports [1]. We encountered in clinical work of 2 cases of leukemia patients after blood group variation occurs, are as follows. Case data 1, male, 28 years old, in April 2011 no obvious incentive to appear fatigue, dizziness, nausea, loss of appetite, general malaise symptoms, accompanied by high fever, the highest body temperature of 39.5 ℃, oral blood blisters, bleeding gums. blood