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健康人群机体通过胰岛素分泌的严密调控使血浆葡萄糖浓度保持在正常水平,包括持续低浓度的基础胰岛素分泌和进餐引发的餐时胰岛素分泌。糖尿病胰岛素治疗中的最大挑战是尽可能地模拟正常个体生理模式的内源性胰岛素分泌的特点。基础胰岛素可通过抑制糖原和脂肪分解从而保证空腹及每餐间血糖正常平稳。血糖的有效控制不仅指将血糖降至接近于正常水平,还包括维持血糖的稳定性。糖尿病治疗中血糖的变异性会妨碍患者获得良好的血糖控制,增加低血糖风险。既往研究还提示糖尿病患者个体内空腹血糖变异性是2型糖尿病(T2DM)患者视网膜病变和死
The health of the human body through the tight control of insulin secretion to maintain normal plasma glucose concentrations, including sustained low concentrations of basal insulin secretion and meal-induced meal insulin secretion. The biggest challenge in diabetic insulin therapy is to mimic as much as possible the physiological characteristics of endogenous insulin secretion in normal individuals. Basal insulin by inhibiting glycogen and lipolysis in order to ensure fasting and blood sugar normal and stable between meals. Effective control of blood sugar not only refers to the blood sugar dropped to near normal levels, but also to maintain the stability of blood sugar. The variability of blood glucose during diabetes therapy can prevent patients from obtaining good glycemic control and increase the risk of hypoglycemia. Previous studies have also suggested that individuals with diabetes have impaired fasting glucose variability in patients with type 2 diabetes mellitus (T2DM)