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目的:探讨ABO新生儿溶血病血清学试验检测结果与新生儿高胆红素血症发生率的关系。方法:在孕妇分娩前和新生儿出生后分别进行ABO、RhD血型鉴定。对母/子血型为O/A(B)、RhD(+)组合的375例新生儿进行新生儿溶血病血清学试验检测,调查其高胆红素血症的发生率,并与393例ABO血型相合新生儿进行对照。结果:ABO新生儿溶血病血清学试验阳性组新生儿高胆红素血症的发生率显著高于对照组(χ2=66.91,P<0.01)和试验阴性组(χ2=34.40,P<0.01)。血清学三项试验以放散试验敏感性最高(67.29%),DAT(93.28%)特异性最高。结论:ABO新生儿溶血病血清学试验结果对预判新生儿高胆红素血症发生有一定的临床意义,早期对母子ABO血型不合的新生儿进行血清学试验检测是早期诊断新生儿高胆红素血症的有效方法。
Objective: To investigate the relationship between ABO neonatal hemolytic disease serological test results and the incidence of neonatal hyperbilirubinemia. Methods: ABO and RhD blood group were identified before delivery and after birth. A total of 375 newborns with a combination of O / A (B) and RhD (+) were tested for serological tests of hemolytic disease in newborns and the incidence of hyperbilirubinemia was investigated. The results were compared with 393 cases of ABO Blood-matched neonatal control. Results: The incidence of neonatal hyperbilirubinemia in the positive group of neonatal hemolytic disease seropositive was significantly higher than that of the control group (χ2 = 66.91, P <0.01) and the negative group (χ2 = 34.40, P <0.01) . Serum three tests to release test the highest sensitivity (67.29%), DAT (93.28%) the highest specificity. Conclusion: The results of serological tests of neonatal hemolytic disease in ABO have certain clinical significance in predicting hyperbilirubinemia in neonates. Early detection of serological tests in neonates with abnormal ABO genotypes of mother and child is an early diagnosis of neonatal hyperbilirubinemia An effective method of erythroleukemia.