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目的观察西地那非联合硫酸镁治疗新生儿持续性肺动脉高压(PPHN)的临床疗效。方法将91例PPHN患儿随机分为MgSO_4组43例和联合组48例,联合组给予西地那非及MgSO_4,MgSO_4组仅给予MgSO_4治疗。对比治疗前后2组的肺动脉压和氧合指数,同时记录血气分析指标检测数据,以判定治疗效果。结果治疗前2组的肺动脉压及氧合指数比较差异无统计学意义(P>0.05),治疗后2组肺动脉压均降低,氧合指数均升高,且联合组变化幅度大于MgSO_4组,差异均有统计学意义(P<0.05)。联合组的治疗总有效率为89.58%高于MgSO_4组的72.09%,差异有统计学意义(P<0.05)。结论治疗PPHN患儿时使用西地那非及MgSO_4可有效降低肺动脉压及改善临床疗效。
Objective To observe the clinical efficacy of sildenafil combined with magnesium sulfate in the treatment of persistent pulmonary hypertension (PPHN) in neonates. Methods Ninety-one children with PPHN were randomly divided into three groups: 43 cases in the MgSO_4 group and 48 cases in the combined group. Sildenafil and MgSO_4 were given to the combined group and MgSO_4 only in the MgSO_4 group. Comparing the two groups before and after treatment of pulmonary arterial pressure and oxygenation index, while recording blood gas analysis index test data to determine the treatment effect. Results There was no significant difference in pulmonary arterial pressure and oxygenation index between the two groups before treatment (P> 0.05). After treatment, both pulmonary arterial pressure and oxygenation index were increased in both groups, and the changes in combined group were greater than those in MgSO 4 group All were statistically significant (P <0.05). The total effective rate of the combination group was 89.58% higher than that of the MgSO 4 group (72.09%), the difference was statistically significant (P <0.05). Conclusion The treatment of PPHN children with sildenafil and MgSO 4 can effectively reduce the pulmonary arterial pressure and improve clinical efficacy.