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目的:研究高效抗逆转录病毒治疗(HAART)对AIDS患者血清中MCP-1、MSP水平的影响。方法:采用ELISA法检测40例经HAART3个月的国内AIDS患者及84例经HAART3至6年的德国患者血清MCP-1、MSP的水平,荧光定量PCR测定HIV-RNA滴度,流式细胞术检测CD4+T细胞计数。结果:HIV-1感染者血清MCP-1的水平显著高于正常人群(P<0.01),MSP则显著低于正常人群(P<0.01);经短期HAART(3月)后,MCP-1水平下降(P<0.01),MSP无明显改变;长期HAART(3至6年)后MCP-1水平显著升高(P<0.01),而MSP显著下降(P<0.01),MCP-1和MSP水平的变化呈负相关(r=-0.99,P=0.029)。结论:MCP-1、MSP与AIDS病程进展有密切关系,HAART对AIDS患者MCP-1、MSP水平有显著的改变,进而改善患者病程进展。
Objective: To investigate the effect of HAART on serum MCP-1 and MSP levels in AIDS patients. Methods: Serum levels of MCP-1 and MSP in 40 HAART patients aged 3 months and 84 German HAART patients aged 3 to 6 years were measured by ELISA. HIV-RNA titer was determined by fluorescence quantitative PCR. Flow cytometry CD4 + T cell count was measured. Results: The serum levels of MCP-1 in HIV-1 infected patients were significantly higher than those in normal controls (P <0.01) and MSP was significantly lower than that in normal controls (P <0.01). After short-term HAART (March) (P <0.01), MSP had no significant change; MCP-1 level increased significantly (P <0.01) and MSP decreased significantly (P <0.01) The changes were negatively correlated (r = -0.99, P = 0.029). CONCLUSION: There is a close relationship between MCP-1, MSP and the development of AIDS. HAART significantly changes the level of MCP-1 and MSP in patients with AIDS, thus improving the course of disease.