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优立新为氨苄青霉素与青霉烷砜的合剂,利用青霉烷砜的不可逆β-内酰胺酶抑制作用,增强了氨苄青霉素对耐药菌株的杀菌活性。本文从体内杀菌活性及其对呼吸系感染的疗效两方面进行了研究和观察。一、方法: (一)血清杀菌活性的对比: 1.实验对象:健康志愿者10人(男5,女5,平均年龄32.6±6.3岁) 2.抗菌药物:对同一受试者先后以氨苄青霉素2g(华津制药厂),优立新3g(含氨苄青霉素2g,青霉烷砜1g,美国辉瑞公司制)静注。 3.受试菌珠:我院临床分离的金葡菌,变形杆菌,绿脓杆菌,阴沟杆菌,不动杆菌,大肠杆菌,肺炎杆菌各三珠。 4.实验方法:(1)参照WHO质控标准配制菌悬液、最终含菌量约为6 ×10~5CFu/ml。(2)置各种菌悬液与不同浓度血清混合液于培养板各孔内,孵
You newly established ampicillin penicillin and penicillin mixture, the use of penicillin sulfone irreversible β-lactamase inhibition, enhanced ampicillin resistance to drug-resistant strains of bacteria. This article from the bactericidal activity in vivo and its effect on respiratory infections were studied and observed. First, the method: (A) Comparison of serum bactericidal activity: 1. Experimental subjects: 10 healthy volunteers (male 5, female 5, average age 32.6 ± 6.3 years) 2. Antibacterial drugs: the same subject successively with ampicillin Penicillin 2g (Huajin Pharmaceutical Factory), You Li new 3g (containing ampicillin 2g, penicillin 1g, Pfizer made) intravenous injection. 3. Test bacteria: clinical isolates of Staphylococcus aureus, Proteus, Pseudomonas aeruginosa, cloacae, Acinetobacter, Escherichia coli, Klebsiella pneumoniae three beads. 4. Experimental methods: (1) According to WHO quality control standard bacterial suspension preparation, the final bacteria content of about 6 × 10 ~ 5CFu / ml. (2) Set a variety of bacterial suspension with different concentrations of serum mixture in the wells of the culture plate, hatch