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目的 观察糖皮质激素必可酮吸入、人脾转移因子与曲尼司特三者联合应用预防哮喘发作的疗效。方法 将60例符合哮喘诊断标准的缓解期哮喘患者随机分为两组。治疗组于哮喘发作季节来临前2月始予以必可酮气雾剂200μg吸入,每日2次;人脾转移因子皮下注射2ml,每隔3dl次;曲尼司特100mg,1d2次口服,疗程为3个月。对照组单用酮替芬1mg,1d2次,用药时间、疗程和疗效评价同治疗组。结果 治疗组总有效率96.7％,对照组总有效率60％,两组疗效差异显著(P<0.01)。结论 必可酮吸入、人脾转移因子与曲尼司特联合应用是预防哮喘发作的一种安全而有效的方法,值得临床推广应用。
Objective To observe the efficacy of corticosteroid inhalation, human spleen transfer factor and tranilast combination in the prevention of asthma attacks. Methods Sixty patients with remission asthma who were diagnosed as asthma were randomly divided into two groups. In the treatment group, 200 μg of beclomethasone aerosol was inhaled twice a day before onset of the asthma attack. 2 ml of human spleen metastasis factor was injected subcutaneously twice a day for 3 days. Tranilast was administrated 100 mg once daily for 2 days. For 3 months. The control group was treated with ketotifen 1 mg, 1d2 times only, the time of treatment, the course of treatment and the evaluation of the curative effect were the same as the treatment group. Results The total effective rate was 96.7% in the treatment group and 60% in the control group, with significant difference between the two groups (P <0.01). Conclusion Combination of inhaled beclomethasone, human splenic transfer factor and tranilast is a safe and effective method to prevent asthma attacks, which is worthy of clinical application.