目的　研究伴胸腺瘤重症肌无力的临床特点。方法　对经手术病检证实的 96例MG伴胸腺瘤患者的临床资料进行回顾性分析 ,并采用 χ2 检验及t检验与 114 9例经影像学检查无胸腺瘤表现的MG患者进行比较。结果　胸腺瘤组男性发病者多 (男∶女 =1 82∶1) ,且多于 30岁后发病 (71 9% ) ,以肢体无力和延髓症状首发者多见 (4 3 8% ) ,按改良Os serman分型 ,以Ⅲ型和Ⅳ型为主 (4 5 8% ) ,危象发生率高 (38 5 % ) ,病死率高 (8 3 % )。结论　伴胸腺瘤的重症肌无力有其独特临床特点 ,充分认识这些特点将有利于指导对这类患者的临床诊断和治疗 Objective To study the clinical features of thymoma with myasthenia gravis. Methods The clinical data of 96 patients with MG with thymoma confirmed by surgery and pathology were retrospectively analyzed and compared with 1149 patients with MG without thymoma by χ2 test and t test. Results Most of the male patients in the thymoma group (male: female = 1: 82: 1) were more likely to develop disease after 30 years of age (71.9%), were more likely to have limb weakness and bulbar symptoms (43.8% Osserman classification was improved mainly in type Ⅲ and type Ⅳ (45.8%), the crisis rate was high (38.5%) and the case fatality rate was high (83%). Conclusion Myasthenia gravis associated with thymoma has its own unique clinical features, fully aware of these features will help guide the clinical diagnosis and treatment of such patients