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我院曾在一批10％葡萄糖注射液生产过程中,经灭菌后,进行澄明度检查时,发现部分输液瓶胶塞上有红色斑点,影响这批产品的质量。后经检查,发现这红色斑点是来自用于处理胶塞的不锈钢夹层锅内的铜制活动隔板上的Cu~(2+),在氢氧化钠处理胶塞时,加热情况下,Cu~(2+)与NaOH生成淡蓝色的氢氧化铜(Cu(OH)_2)沉淀粘附在夹层锅壁周围,加上处理的胶塞量较多,用水冲洗不彻底,致Cu(OH)_2未完全除尽,
In our hospital in a group of 10% glucose injection during the production process, after sterilization, the degree of clarity check, we found that some infusion bottle stopper with red spots, affecting the quality of these products. After examination, found that the red spots are from the stainless steel sandwich used to deal with the rubber plug in the pot of copper on the activities of the separator on the barrier, sodium hydroxide in the processing of rubber stopper, the heating case, Cu ~ (Cu2 +) and NaOH to form light blue copper hydroxide (Cu (OH) 2). The precipitate adhered to the wall of the sandwich pot and the volume of the treated rubber plug was large. _2 not completely divisible,