论文部分内容阅读
目的:探讨系膜增生性肾小球肾炎(MsPGN)患者血浆中血栓调节蛋白(PTM)的水平与肾功能、蛋白尿、凝血功能、血脂之间的关系。方法:54例经肾穿刺活检明确诊断的MsPGN患者,采用酶联免疫吸附法(ELISA)检测血浆PTM水平。依照蛋白尿的程度将病人分为两组:(1)大量蛋白尿组,24h尿蛋白定量大于3.5 g。(2)少量蛋白尿组,24 h尿蛋白定量小于3.5 g。结果:大量蛋白尿组的PTM浓度、纤维蛋白原(Feb)、甘油三酯和总胆固醇均比少量蛋白尿组高,两组之间有统计学差异(P<0.05)。而少量蛋白尿组的白蛋白比大量蛋白尿组高(P<0.05),两组CCr相比没有显著性差异。所有病人的PTM与其他指标的相关性分析显示PTM与Feb和蛋白尿呈正相关(r=0.371r、=0.505,P均<0.05),PTM随着Feb和蛋白尿的增加而增高。PTM与白蛋白呈负相关(r=-0.491,P<0.05),PTM随着白蛋白降低而增高。PTM与CCr、甘油三酯和总胆固醇无相关性(P>均0.05)。结论:血浆PTM水平与蛋白尿的程度相关。血浆PTM与蛋白尿的水平不仅是(MsPGN)病变程度的指标,并且可为指导治疗和判断预后提供依据。
Objective: To investigate the relationship between plasma thrombomodulin (PTM) levels and renal function, proteinuria, coagulation function and blood lipid in patients with mesangial proliferative glomerulonephritis (MsPGN). Methods: Fifty - four patients with MsPGN diagnosed by renal biopsy and plasma PTM level were detected by enzyme - linked immunosorbent assay (ELISA). According to the degree of proteinuria, the patients were divided into two groups: (1) a large number of proteinuria group, 24h urinary protein was greater than 3.5 g. (2) a small amount of proteinuria, 24 h urinary protein less than 3.5 g. Results: The PTM concentration, fibrinogen (Feb), triglyceride and total cholesterol in the albuminuria group were higher than those in the small proteinuria group. There was a significant difference between the two groups (P <0.05). However, albumin in a small amount of proteinuria group was higher than that in large proteinuria group (P <0.05). There was no significant difference between the two groups in CCr. Correlation analysis of PTM and other parameters in all patients showed that PTM was positively correlated with Feb and proteinuria (r = 0.371r, = 0.505, P <0.05). PTM increased with the increase of Feb and proteinuria. PTM was negatively correlated with albumin (r = -0.491, P <0.05), while PTM increased as albumin decreased. There was no correlation between PTM and CCr, triglyceride and total cholesterol (P> 0.05). Conclusions: Plasma PTM levels correlate with the degree of proteinuria. Plasma PTM and proteinuria levels not only (MsPGN) lesions index, and can provide guidance for the treatment and prognosis.