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目的 研究丙烯腈对雌性大鼠血清中雌二醇 (E2 )、卵泡刺激素 (FSH)及黄体生成素 (LH)水平及卵巢、子宫、肾上腺病理改变的影响。方法 采用放射免疫法测定丙烯腈经皮下注射染毒 30天雌性大鼠血清中上述各激素的水平 ;光镜观察卵巢、子宫和肾上腺的病理改变。结果 各染毒组与对照组比较三种激素水平差异均无显著性 (P >0 0 5 ) ;但卵巢及肾上腺有不同程度的病理改变。结论 在此条件下 ,丙烯腈对雌性大鼠的内分泌激素无影响 ,但对生殖系统有直接损害作用。
Objective To investigate the effects of acrylonitrile on the serum estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) and the pathological changes of ovary, uterus and adrenal in female rats. Methods The levels of these hormones in the sera of 30-day-old female rats exposed to acrylonitrile by subcutaneous injection of acrylonitrile were determined by radioimmunoassay. The pathological changes of ovaries, uterus and adrenal glands were observed with light microscope. Results There was no significant difference in the levels of the three hormones among the infected and control groups (P> 0.05). However, the ovarian and adrenal glands had different pathological changes. Conclusions Under these conditions, acrylonitrile has no effect on endocrine hormones in female rats, but has a direct effect on the reproductive system.