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硝普钠是一种肌肉松弛剂,因其具有一定的毒性,被遗弃百余年之后,今又重新被重视起来。近年来,硝普钠用于颅内血管手术中作为控制性人工低血压药物,收效卓著。本文着重探讨硝普钠的临床效用及其毒性、。硝普钠(Sodium Nitroprusside)的化学分子式结构简单(Na_2-NoFe(CN)_5·2H_2O),其效用主要归功干亚硝基NO,其毒性归因于铁氰基(Fe(CN)_5。Ⅰ.降压作用:硝普钠具有强力的血管扩张作用。此乃NO基对动脉之平滑肌纤维具有强力的松弛作用之故。如用-NH_3基取代-NO基而形成氨戊氰铁酸盐,其降压作用顿告消失,即为明证。其它氮衍
Sodium nitroprusside is a muscle relaxant, because of its toxicity, abandoned more than a hundred years later, now again being valued. In recent years, sodium nitroprusside for intracranial vascular surgery as a controlled hypotensive drug, remarkable success. This article focuses on the clinical utility and toxicity of sodium nitroprusside. The chemical structure of sodium nitroprusside is simple (Na 2 -NFe (CN) 5 · 2H 2 O), its utility is mainly due to the dry nitroso NO, its toxicity is attributed to ferrocyanide (Fe (CN) Antihypertensive effect: Sodium nitroprusside has a strong vasodilator effect, which is based on the NO-based arteries smooth muscle fibers have a strong relaxation effect Therefore, such as the -NH_3 group substituted -NO group and the formation of amoxicillin, The antihypertensive effect suddenly disappeared, that is evidence. Other nitrogen derivatives