论文部分内容阅读
目的了解吸入皮质激素类药物———布地奈德气雾剂对儿童咳嗽变异性哮喘的作用。方法观察布地奈德吸入治疗 (≤ 4 0 0 μg)前后肺功能的变化。结果用力肺活量 (FVC)、1秒用力呼气容积 (FEV1)、呼气峰流速 (PEFR)测定值接近正常儿童 ,而肺活量最大呼气流速 (FEF) 2 5 %～ 75 %明显低于正常儿童测定值。治疗 6个月后患儿FEF 2 5 %～75 %较治疗前有显著意义的改善 (P <0 .0 1)。结论咳嗽变异性哮喘患儿存在小气道功能障碍 ,应按哮喘常规治疗给予较长时间的皮质激素吸入。
Objective To investigate the effect of inhaled corticosteroids - budesonide aerosol on children with cough variant asthma. Methods The changes of lung function before and after the inhalation of budesonide (≤ 400 μg) were observed. Results FVC, FEV1 and PEFR were close to those of normal children, while the maximum expiratory flow rate (FEF) 25% -75% of vital capacity was significantly lower than that of normal children measured value. After 6 months of treatment, children with FEF 2 5% ~ 75% than the treatment before significant improvement (P <0.01). Conclusions There are small airway dysfunction in children with cough variant asthma. Corticosteroid inhalation should be given for a longer time according to routine asthma treatment.