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作者于1977年起采用粗制的HLI(人白细胞干扰素)局部应用治疗头颈部肿瘤。结果提示干扰素抗肿瘤活性表现为对肿瘤细胞的直接作用和激发宿主免疫系统反应两个方面。作者选择了皮肤肿瘤作为研究对象,因皮肤癌常见、易于临床观察、行局部注射简便易行,容易取得活检组织,并且可根据治疗后推延外科手术的时间来证明干扰素的抗肿瘤特性。在1977～1979年间,30例癌瘤患者接受了干扰
The authors used crude HLI (human leukocyte interferon) for topical treatment of head and neck tumors since 1977. The results suggest that the antitumor activity of interferon appears to be a direct effect on tumor cells and stimulate the host immune system response. The authors chose skin tumors as the research object. Because skin cancer is common, easy to observe clinically, local injections are easy, biopsy can be easily obtained, and the anti-tumor properties of interferon can be demonstrated based on the time after surgery is postponed. Between 1977 and 1979, 30 cancer patients received interference