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目的:通过meta分析探讨雄激素受体(AR)基因CAG重复多态性与良性前列腺增生(BPH)和前列腺癌(PCa)发病风险的关系。方法:检索国内外大型数据库发表的AR基因CAG重复多态性与BPH和PCa相关性的文献,基于异质性检验的结果,分别采用M-H固定效应模型和随机效应模型合并比值比(OR)效应量,采用Begg和Egger偏倚分析评估本项meta分析的发表偏倚,系统评价AR基因CAG重复多态性与BPH和PCa发病风险的关系,并按种族进行分层分析。结果:检索获得文献29篇,最终纳入4篇符合条件的文献,累计BPH患者485例、PCa患者767例、正常对照组709例。BPH组和正常对照组间不存在异质性,M-H固定效应模型合并效应量后提示低CAG重复多态性与BPH无相关性。PCa组和BPH组及对照组间均存在异质性,随机效应模型提示低CAG重复多态性与PCa的风险呈正相关(OR PCa/对照=1.45,OR PCa/BPH=1.86,OR PCa/(BPH+对照)=1.66)。种族分层的亚组分析提示,低CAG重复多态性与PCa发病风险在种族间存在差异。Begg和Egger偏倚分析显示各组比较中均无显著发表偏倚。结论:AR受体低CAG重复多态性与PCa发病风险呈正相关,与BPH发病风险无相关性。
Objective: To investigate the relationship between CAG repeat polymorphism of androgen receptor (AR) gene and the risk of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) by meta-analysis. Methods: The literature about the correlation between CAG repeat polymorphism of AR gene and BPH and PCa published in large databases at home and abroad was searched. Based on the results of heterogeneity test, MH fixed effect model and random effect model were used to compare odds ratio (OR) The Begg and Egger bias analysis was used to evaluate the publication bias of this meta-analysis. The relationship between CAG repeat polymorphism of AR gene and the risk of BPH and PCa was systematically evaluated and stratified by race. Results: A total of 29 articles were retrieved from the literature and 4 articles were finally included. A total of 485 cases of BPH, 767 cases of PCa and 709 cases of normal control were included. There was no heterogeneity between BPH group and normal control group. M-H fixed effect model combined effect showed no correlation between low CAG repeat polymorphism and BPH. There was a heterogeneity between PCa group and BPH group and control group. The random effect model suggested that there was a positive correlation between low CAG repeat polymorphism and PCa risk (OR PCa / control = 1.45, OR PCa / BPH = 1.86, OR PCa / BPH + control) = 1.66). Racial stratified subgroup analyzes suggest that there is a racial difference between low CAG repeat polymorphisms and PCa risk. Begg and Egger bias analysis showed no significant publication bias among the groups. Conclusion: The low CAG repeat polymorphism of AR receptor is positively correlated with the risk of PCa, but not with the risk of BPH.