The problem of bacterial drug resistance has become one of the most serious threats to global health and safety.Acinetobacter baumannii is an important opportunistic human pathogen that causes various clinical manifestations (bacteremia,urinary infection,secondary meningitis) in immunocompromised patients.Unfortunately,multi-drug resistant A.baumannii (MDRAB) is emerging,which leads to considerable morbidity and mortality,especially responsible for healthcare-associated infections in intensive care units (ICUs) [1,2].