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c-kit原癌基因的编码产物为一种酪氨酸激酶受体,其与血小板衍生的生长因子受体和CSF-1受体高度同源。研究已阐明这种受体调节许多个体发生的非相关细胞系的发展,如造血细胞、生殖细胞等。这些多效活性通过糖蛋白配体的结合而介导的,如干细胞因子(SCF).鉴于已经显示肿瘤的转化与c-kit表达的正性或负性调节相关,作者对38例良性和31例恶性甲状腺病变进行了Northern和Western印迹分析。用细胞外区域染色c-kit mAb证
The encoded product of the c-kit proto-oncogene is a tyrosine kinase receptor that is highly homologous to platelet-derived growth factor receptors and CSF-1 receptors. Studies have elucidated that this receptor regulates the development of many individual unrelated cell lines, such as hematopoietic cells, germ cells, and the like. These pleiotropic activities are mediated through the binding of glycoprotein ligands, such as stem cell factor (SCF). Given that it has been shown that the transformation of tumors is associated with positive or negative regulation of c-kit expression, the authors have studied 38 cases of benign and 31 Cases of malignant thyroid lesions were analyzed by Northern and Western blots. C-kit mAb staining with extracellular regions