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目的探讨肿瘤坏死因子 α(TNF α)和细胞间粘附分子 1(ICAM 1)在慢性阻塞性肺疾病 (COPD)发病机制中的作用。方法采用放射免疫法检测 38例COPD患者血清TNF α和ICAM 1水平 ,并以 30例健康人作为对照。结果在COPD急性感染期 ,患者血清TNF α和ICAM 1水平显著高于感染控制期和健康对照组 (P <0 .0 1) ;而且重症感染患者血清TNF α和ICAM 1水平显著高于轻症患者 (P <0 .0 5 )。结论TNF α和ICAM 1参与了COPD肺部感染的发病过程 ,并可作为COPD患者判断病情的一项感染监测指标。
Objective To investigate the role of tumor necrosis factor α (TNF α) and intercellular adhesion molecule 1 (ICAM 1) in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods Serum levels of TNFα and ICAM 1 were measured by radioimmunoassay in 38 COPD patients and 30 healthy controls were used as controls. Results In the acute phase of COPD, serum TNFα and ICAM1 levels were significantly higher than those in the control and healthy controls (P <0.01). Serum levels of TNFα and ICAM1 in patients with severe infections were significantly higher than those in mild cases Patients (P <0.05). Conclusions TNFα and ICAM-1 are involved in the pathogenesis of pulmonary infection in COPD and can be used as an indicator of infection in COPD patients.