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目的探讨烟草暴露与肺结核发病的关系,揭示肺结核危险因素。方法采用病例对照设计,应用自行设计的问卷调查济宁市136例肺结核病例和149例对照的烟草暴露及其它肺结核潜在危险因素情况,并进行单因素和多因素条件Logistic回归分析。结果单因素分析显示:吸烟(OR=6.011,OR95%CI:3.648～9.905,P=0.000)和已戒烟(OR=5.125,OR95%CI:2.100～12.507,P=0.000)有统计学意义;被动吸烟(OR=1.042,OR95%CI:0.642～1.693,P=0.868)无统计学意义。多因素条件Logistic回归分析显示:吸烟(OR=6.282,OR95%CI:3.188～12.382,P=0.000)和已戒烟(OR=9.938,OR95%CI:2.851～34.634,P=0.000)均是肺结核危险因素。结论有吸烟史是肺结核发病的危险因素。
Objective To explore the relationship between tobacco exposure and the incidence of pulmonary tuberculosis and to reveal the risk factors for tuberculosis. Methods A case-control study was designed to investigate the tobacco exposure and other potential risk factors of tuberculosis in 136 pulmonary tuberculosis cases and 149 control cases in Jining City by means of a self-designed questionnaire. Univariate and multivariate conditional Logistic regression analysis was performed. Results Univariate analysis showed that smoking (OR = 6.011, OR95% CI: 3.648-9.905, P = 0.000) and smoking cessation (OR = 5.125, OR95% CI: 2.100-12.507, P = 0.000) Smoking (OR = 1.042, OR95% CI: 0.642-1.693, P = 0.868) was not statistically significant. Multivariate logistic regression analysis showed that smoking (OR = 6.282, OR 95% CI: 3.188-12.382, P = 0.000) and smoking cessation (OR = 9.938, OR 95% CI: 2.851-34.634, P = 0.000) factor. Conclusion Smoking history is a risk factor for tuberculosis.