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法西达(Fansidar)是一个复方制剂,每安瓿含乙胺嘧啶25mg和周效磺胺500mg,用于预防和治疗疟疾。这两种药物分别抑制疟原虫的叶酸合成过程中两种不同的酶(二氢叶酸还原酶和二氢喋酸合成酶)。本文介绍了用高效液相色谱方法同时对血浆内的乙胺嘧啶和周效磺胺含量进行测
Fansidar is a combination preparation containing 25 mg of pyrimethamine and 500 mg of sulfasalate ampoules for the prophylaxis and treatment of malaria. The two drugs inhibit two different enzymes (dihydrofolate reductase and dihydroprehide synthase, respectively) during the folic acid synthesis of Plasmodium. This article describes the use of high performance liquid chromatography simultaneous plasma pyrimethamine and psoralen content test