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己酮可可碱(1)与其它嘌呤衍生物不同,具有多种药理学特性。1可增加红细胞弹性,并可降低血小板聚集,故具有显著的血液流变学活性。由于血液流动性增强,使微循环系统,尤其是缺血区的血流增加,这是1能矫正器官功能损害的基础。长期口服此药有抗血栓形成作用,可使纤溶活性增加,而血浆纤维蛋白原水平降低。有人认为,1可阻止血管内血小板的止血反应,抑制纤维素在肾小球沉积,防止进行性闭塞的发生。1可稳定地作用于细胞和溶酶体膜,同时有抗聚集作用,且能阻止生物活性物质和炎症介体的释放。1作用的基本生化机制在于选择性地抑
Pentoxifylline (1), unlike other purine derivatives, has a variety of pharmacological properties. 1 can increase the elasticity of red blood cells and reduce platelet aggregation, it has significant hemorheological activity. Due to increased blood flow to the microcirculation system, especially in ischemic areas increased blood flow, which is a can correct the basis of organ dysfunction. Long-term oral antithrombotic effect of the drug, can increase fibrinolytic activity, while the level of plasma fibrinogen decreased. Some people think that 1 can prevent the hemostatic reaction of intravascular platelets, inhibit the deposition of cellulose in the glomeruli, to prevent the occurrence of progressive occlusion. 1 can stably act on cells and lysosomal membranes with antiaggregation and can prevent the release of bioactive substances and inflammatory mediators. 1 The basic biochemical mechanism of action lies in the selective suppression