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应用肝脏原位灌注模型，探讨了内皮素１（ＥＴ１）在内毒素所致肝损伤中的作用。选用Ｗｉｓｔａｒ大鼠２４只，分为对照组、ＥＴ１组、内毒素组、内毒素＋ＥＴ１抗体组。观察了肝组织中ＥＴ１、一氧化氮（ＮＯ）、前列环素（ＰＧＩ２）、乳酸脱氢酶（ＬＤＨ）、丙二醛（ＭＤＡ）、三磷酸腺苷（ＡＴＰ）和肝组织学变化。结果显示：内毒素能使肝组织ＥＴ１含量增加；内毒素和ＥＴ１均能使细胞脂质过氧化物形成和酶的漏出，还能使肝细胞浊肿变性；ＥＴ１抗体能部分拮抗内毒素所致的肝损伤。结果表明：ＥＴ１参与了内毒素所致的肝损伤作用。
In situ perfusion model of liver was used to investigate the role of endothelin-1 (ET-1) in liver injury induced by endotoxin. 24 rats were selected Wis tar rats, divided into control group, ET 1 group, endotoxin group, endotoxin + ET 1 antibody group. The liver histological changes of ET-1, NO, PGI2, LDH, MDA, ATP and liver were observed. The results showed that: endotoxin can increase the content of liver ET 1; endotoxin and ET 1 can make the formation of lipid peroxidation and enzyme leakage, but also to degeneration of hepatocellular carcinoma; ET 1 antibody can Partial antagonism of endotoxin-induced liver injury. The results showed that: ET 1 is involved in liver injury caused by endotoxin.