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目的 探讨脑硬死患者急性期血小板膜P -选择素 (CD6 2p)的表达及其与临床神经功能缺损程度的关系。方法 用流式细胞术测定 41例急性期脑梗死患者血小板膜CD6 2 p的表达。 结果 轻、中、重型脑梗死患者CD6 2 p的表达分别为 (1.38± 0 .2 9) %、(3.15± 1.5 8) %、(10 .46± 5 .0 7) % ,与正常对照组 (1.5 6± 0 .17) %比 ,轻型脑梗死患者CD6 2p的表达无显著性差异 (P >0 .0 5 ) ,中、重型脑梗死患者CD6 2 p的表达显著升高 (P <0 .0 5和0 .0 1)。结论 脑梗死患者急性期血小板膜CD6 2 p的表达与临床神经功能缺损程度有关。
Objective To investigate the expression of platelet membrane P-selectin (CD6 2p) and its relationship with the degree of clinical neurological deficits in patients with acute cerebral encephalomyelitis. Methods Flow cytometry was used to determine the platelet membrane CD6 2 p expression in 41 patients with acute cerebral infarction. Results The expressions of CD6 2 p in mild, moderate and severe cerebral infarction patients were (1.38 ± 0.29)%, (3.15 ± 1.58)%, (10.46 ± 5.07)%, respectively. Compared with the normal control group (1.56 ± 0.17)%, there was no significant difference in the expression of CD62p in patients with mild cerebral infarction (P> 0.05), while the expression of CD62p in patients with moderate or severe cerebral infarction was significantly higher .0 5 and 0 .0 1). Conclusion The expression of platelet membrane CD6 2 p in acute stage of cerebral infarction is related to the degree of clinical neurological deficit.