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目的探讨原发性高血压(EH)患者经非洛地平干预治疗,血清血管紧张素Ⅰ(AⅠ)、血管紧张素Ⅱ(AⅡ)、心钠素(ANF)和醛固酮(ALD)水平的变化及临床意义。方法放射免疫法测定360例EH组和80例非高血压组血清AⅠ、AⅡ、ANF和ALD水平,对其中116例EH患者给予非洛地平干预治疗,80例完成治疗,并接受上述血管活性肽的复查。结果EH患者血清AⅠ、AⅡ和ALD高于对照组(t=7.024,P<0.01;t=5.602,P<0.01;t=13.37,P<0.01),ANF则否(P>0.05);Ⅰ、Ⅱ、Ⅲ期组间四者血清水平的方差检验差异无统计学意义(P均>0.05)。AⅠ与AⅡ,ALD与AⅡ间呈正相关(P均<0.05),AⅠ与ANF,AⅠ与ALD,AⅡ与ANF,ANF与ALD间无相关性(P均>0.05)。80例EH患者,经平均(72±29)d的非洛地平干预治疗后,血清AⅠ显著升高(t=2.101,P<0.05),AⅡ、ANF和ALD水平改变差异无统计学意义(P均>0.05)。结论EH患者血清AⅠ、AⅡ和ALD显著升高,非洛地平可致血清AⅠ显著升高,AⅡ、ANF和ALD则不能。
Objective To investigate the changes of serum angiotensin Ⅰ (AⅠ), angiotensin Ⅱ (AⅡ), atrial natriuretic peptide (ANF) and aldosterone (ALD) in patients with essential hypertension (EH) Clinical significance. Methods The levels of serum AⅠ, AⅡ, ANF and ALD in 360 patients with EH and 80 patients without hypertension were determined by radioimmunoassay. One hundred and sixty-six patients with EH were treated with felodipine, 80 patients completed treatment and received the above vasoactive peptide Review. Results The levels of serum AⅠ, AⅡ and ALD in EH patients were significantly higher than those in control group (t = 7.024, P <0.01; t = 5.602, P <0.01; There was no significant difference in the test of variance between the serum levels of group Ⅱ and group Ⅲ (all P> 0.05). There was a positive correlation between AⅠand AⅡ, ALD and AⅡ (all P <0.05). There was no correlation between AⅠand ANF, AⅠand ALD, AⅡand ANF, ANF and ALD (all P> 0.05). In 80 patients with EH, the serum AⅠwere significantly increased (t = 2.101, P <0.05) and the levels of AⅡ, ANF and ALD had no significant difference after a mean of (72 ± 29) days of felodipine intervention All> 0.05). Conclusions Serum AⅠ, AⅡ and ALD were significantly increased in patients with EH. Felodipine caused a significant increase in serum AⅠ, but no AⅡ, ANF or ALD.