论文部分内容阅读
目的:通过测定乳腺癌患者化疗前、后血清中血管上皮生长因子(VEGF)的浓度变化,以期观察血清VEGF与乳腺癌患者化疗疗效之间的相关性。方法:采用酶联免疫吸附法(ELISA)分别检测60例乳腺癌患者化疗前、后血清VEGF水平,以20名正常健康志愿者血清VEGF水平作为对照。结果:乳腺癌组化疗前血清VEGF含量明显高于对照组(P<0.01),化疗后血清VEGF显著下降(P<0.01)。结论:连续检测血清VEGF的表达水平能在一定程度上帮助临床判断化疗近期疗效及监测肿瘤的进展。
OBJECTIVE: To determine the correlation between serum VEGF and the efficacy of chemotherapy in breast cancer patients by determining the serum concentration of vascular endothelial growth factor (VEGF) before and after chemotherapy in patients with breast cancer. Methods: The levels of serum VEGF in 60 cases of breast cancer patients before and after chemotherapy were detected by enzyme linked immunosorbent assay (ELISA), and the serum levels of VEGF in 20 healthy volunteers were used as controls. Results: The serum VEGF level in breast cancer group before chemotherapy was significantly higher than that in control group (P <0.01). The serum VEGF decreased significantly after chemotherapy (P <0.01). Conclusion: The continuous detection of serum VEGF expression can help to determine the clinical efficacy of chemotherapy and monitor the progress of the tumor to a certain extent.