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目的探讨新生儿缺氧缺血性脑病（HIE）的甲状腺功能改变。方法应用放射免疫的方法测定了36例新生儿缺氧缺血性脑病和20例正常新生儿血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）及甲状腺刺激激素（TSH）。结果HIE患儿与对照组比较，T3、T4明显降低（P＜0．05），中重度HIE组患儿T3明显低于轻度HIE组患儿（P＜0．05）。HIE组TSH与对照组比较无显著性差异（P＞0．05）。结论HIE患儿存在下丘脑－垂体－甲状腺轴功能受损。
Objective To investigate the changes of thyroid function in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Serum triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) were measured in 36 neonates with hypoxic-ischemic encephalopathy and 20 normal neonates by radioimmunoassay. Results Compared with the control group, the levels of T3 and T4 were significantly decreased in HIE children (P <0.05). T3 in HIE children was significantly lower than that in mild HIE children (P <0.05). There was no significant difference between HIE group and control group (P> 0.05). Conclusions Hypothalamic-pituitary-thyroid axis impaired function in children with HIE.