DC作为一种有效的抗原递呈细胞 ,能够始动和调整免疫反应 ,产生两种相反的结果 :免疫反应和免疫耐受。装载抗原之后DC呈现出佐剂的性质 ,即疫苗的功能性成分。越来越多的证据表明 ,DC可以作为一种工具来诱导外周免疫耐受。本文拟对DC应用于疫苗设计 ,触发外周免疫耐受治疗自身免疫病的相关内容作一综述 As a potent antigen presenting cell, DC can initiate and regulate the immune response, resulting in two opposite results: immune response and immune tolerance. After antigen loading, DCs exhibit the properties of adjuvants, ie, the functional components of the vaccine. More and more evidence shows that DC can be used as a tool to induce peripheral immune tolerance. This article intends to review the application of DC in vaccine design and the triggering of peripheral immune tolerance in the treatment of autoimmune diseases