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目的研究多种因素对等待肾移植的终末期肾衰患者体内群体反应性抗体阳性的影响及意义。方法运用酶联免疫吸附试验检测广州南方医院等待肾移植患者血清PRA,分析年龄、性别、妊娠史和输血史等因素与PRA结果的关联性,并采用多因素logistic回归进行分析。结果女性PRA阳性风险是男性的5.591倍(OR 95%CI:3.148~9.931),有输血史者是无输血史者的2.692倍(OR 95%CI:1.543~4.699),有移植史者是无移植史者的5.059倍(OR 95%CI:2.265~11.299)。年龄及妊娠史与PRA阳性无显著关联(P>0.05)。结论性别和输血史为PRA阳性的独立影响因素;年龄和妊娠史与PRA阳性无显著关联;移植史对PRA的影响有待进一步的研究。
Objective To study the effect and significance of multiple factors on the positive of anti-group antibody in vivo in patients with end-stage renal failure waiting for kidney transplantation. Methods The serum PRA of patients waiting for kidney transplantation in Guangzhou Nanfang Hospital were detected by enzyme-linked immunosorbent assay (ELISA). The correlation between PRA and age, gender, pregnancy history and blood transfusion was analyzed. Multivariate logistic regression was used to analyze the association. Results The positive risk of PRA in women was 5.591 times higher than that in men (OR 95% CI: 3.148-9.931). The blood transfusion history was 2.692 times higher than those without transfusion history (OR 95% CI: 1.543-4.699) 5.059 folds of transplant history (OR 95% CI: 2.265 to 11.299). There was no significant correlation between age and pregnancy history and PRA positive (P> 0.05). Conclusions The gender and blood transfusion history are independent influencing factors of PRA positive. There is no significant correlation between age and pregnancy history and PRA positive. The influence of transplantation history on PRA remains to be further studied.