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1985年11月5日至6日美国肝脏病研究协会在芝加哥举行了第36届年会。大会收到乙型肝炎研究的论文多篇,现将有关情况概述于下。一、HBV相关变异株的发现 Wands等将2例仅单克隆放射免疫法(M-RIA)测定HBsAg相关决定簇阳性和杂交分析含有HBV DNA互补核酸序列患者的血清接种入4头黑猩猩(其中2头曾接种重组HBsAg疫苗,并对天然HBV攻击产生保护性免疫;另2头未暴露过任何肝炎病毒,抗-HBs和抗-HBc均阴性)。结果4头动物均在70～170天的潜伏期后发生了急性肝炎。在抗原血症期,检出HBV DNA互补序列,基因组为3.2kb,而在潜伏期或恢
November 5-6, 1985 American Society of Hepatology Research held its 36th annual meeting in Chicago. Congress received many articles on hepatitis B research, the situation is summarized below. First, the discovery of HBV-related mutations Wands and so will only 2 monoclonal antibody radioimmunoassay (M-RIA) determination HBsAg-related determinant positive and hybridization analysis HBV DNA complementary nucleic acid sequence of patients inoculated into 4 chimpanzees (2 The head had been vaccinated with recombinant HBsAg and had protective immunity against natural HBV challenge; the other two had not been exposed to any hepatitis virus, and both anti-HBs and anti-HBc were negative. Results All four animals developed acute hepatitis after a 70-170 day incubation period. In the anti-angiogenic phase, HBV DNA complementary sequence was detected, the genome was 3.2kb, and in the incubation period or recovery