【摘 要】
：
tert-Butyl (R)-3-amino-3-(3-fluorophenyl)propanoate(5) was prepared with conventional debenzylation method. However, the tert-butyl (R)-3-[(S)-1-phenylethyl-ami
【出 处】
：
Chemical Research in Chinese Universities
论文部分内容阅读
tert-Butyl (R)-3-amino-3-(3-fluorophenyl)propanoate(5) was prepared with conventional debenzylation method. However, the tert-butyl (R)-3-[(S)-1-phenylethyl-amino]-3-(3-fluorophenyl) propanoate(6) and tert-butyl (R)-3-amino-3-phenylpropanoate(7) were generated as the byproducts under the general catalytic hydrogenation Pd(OH)2/C-H2 conditions. So a series of experiments was performed to optimize the reaction conditions so that product 5 could be obtained with high purity and yield. Finally an effective catalytic system, Pd/C-HCOOH-CH3OH, was discovered.
However, the tert-Butyl (R) -3-amino-3- (3-fluorophenyl) propanoate was prepared with conventional debenzylation method. amino-3- (3-fluorophenyl) propanoate (6) and tert-butyl (R) -3-amino-3- phenylpropanoate were produced as the byproducts under the general catalytic hydrogenation of Pd H2 conditions. So a series of experiments was performed to optimize the reaction conditions so that product 5 could be obtained with high purity and yield. Finally an effective catalytic system, Pd / C-HCOOH-CH3OH, was discovered.
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