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1例59岁男性因患丙型肝炎,给予干扰素α-1b300万u隔日一次肌内注射;并口服利巴韦林300mg,2次/d。用药约6周,患者出现严重干咳、呼吸困难。T36.3℃;WBC7.72×109/L,N0.82;血气分析:PCO236mmHg,PO248mmHg,SaO287%;胸片示双肺纹理增重,右肺下野斑片状模糊影;胸部CT平扫示双肺弥漫渗出病变,伴下叶膨胀不全。诊断为间质性肺炎。考虑可能与干扰素及利巴韦林治疗有关。停用干扰素及利巴韦林。患者给予阿奇霉素和头孢曲松治疗,1d后呼吸道症状迅速缓解。
A 59-year-old man was given intramuscular injections of interferon alpha-1b (3 million) u every other day for hepatitis C; and ribavirin 300 mg twice daily. Medication for about 6 weeks, patients with severe dry cough, difficulty breathing. T36.3 ℃; WBC7.72 × 109 / L, N0.82; blood gas analysis: PCO236mmHg, PO248mmHg, SaO287%; chest X-ray weight gain of the lungs, Diffuse lung oozed lesions, with the next expansion of the lower leaves. Diagnosis of interstitial pneumonia. Consideration may be related to interferon and ribavirin therapy. Disable interferon and ribavirin. Patients given azithromycin and ceftriaxone treatment, 1d after the rapid relief of respiratory symptoms.