维生素K1注射液临床主要用于维生素K缺乏引起Ⅱ、Ⅶ、Ⅸ、Ⅹ凝血因子合成障碍或异常而致的出血。有关维生素K1注射液引起的不良反应有不少报道,主要表现有全身性损害;呼吸系统损害等[1]。但是在实践过程中发现,基层医生对其不良反应还没有引起足够的重视。我科应用维生素K1主要用于预防头孢类抗生素导致的出血和预防新生儿出血,在应用过程中出现了2例严重不良反应,现报告如下。例1:患儿,女,7个月,主因咳嗽5天入院,双肺可闻及干性罗音,胸部X线提示双肺纹理增粗紊乱,血常规WBC11× Vitamin K1 injection clinical is mainly used for vitamin K deficiency caused Ⅱ, Ⅶ, Ⅸ, Ⅹ coagulation factor synthesis disorders or abnormal bleeding. There are many reports of adverse reactions caused by vitamin K1 injection, the main manifestations of systemic damage; respiratory damage [1]. However, in practice, it has been found that grassroots doctors have not given enough attention to their adverse reactions. In our department, vitamin K1 is mainly used to prevent the bleeding caused by cephalosporin antibiotics and prevent bleeding in newborns. Two serious adverse reactions occurred during the application. The report is as follows. Example 1: children, women, 7 months, the main cough for 5 days admitted to the hospital, the lungs can be heard and dry rales, chest X-ray prompted thickening of bilateral lungs disorder, blood WBC11 ×