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目的:了解人白细胞抗原(human leukocyte antigen,HLA)表达与单疱病毒性角膜炎(Herpessimplex keratitis,HSK)的关系,揭示HSK发病机制。方法:应用流式细胞术(Flow cytometry,FCM)检测32例HSK患者(溃疡型及基质型各16例)外周血HLA-ABC、HLA-DR、HLA-DP、HLA-DQ抗原表达,并与7例正常人进行对照。结果:溃疡型及基质型HSK患者外周血HLA-ABC抗原表达均明显低于正常人,HLA-DR及HLA-DP抗原表达均明显高于正常人,溃疡型与基质型HLA抗原表达均无明显差异。结论:HSK患者免疫反应模式与正常人不同,具有这种免疫反应模式机体不仅不能正常清除感染的病毒,而且有自身免疫的参与,从而导致HSK的发生。眼科学报1998;14:61—63。
Objective: To investigate the relationship between human leukocyte antigen (HLA) expression and herpessimplex keratitis (HSK) and to reveal the pathogenesis of HSK. Methods: The expression of HLA-ABC, HLA-DR, HLA-DP and HLA-DQ antigen in peripheral blood of 32 patients with HSK (16 in ulcer type and in stroma type) was detected by flow cytometry (FCM) Seven normal controls. Results: The expression of HLA-ABC antigen in peripheral blood of patients with ulcer type and stromal HSK was significantly lower than that of normal people, the expression of HLA-DR and HLA-DP antigen were significantly higher than that of normal people, and the expression of HLA- difference. Conclusion: The immune response mode of HSK patients is different from that of normal people. With this immune response model, the body not only can not clear the infected virus normally but also has the autoimmune involvement, leading to the occurrence of HSK. Ophthalmic Science 1998; 14: 61-63.