本文观察了脑室内注射甲状旁腺素(PTH)和降钙素(CT)对小鼠痛阈及对脑突触小体~(45)Ca摄取的彩响。结果表明,PTH(0.1U、0.4U、0.8U)均使小鼠痛阈明显降低,与此相反,CT(0.5U、1.0U、2.0U)则使小鼠痛阈显著上升,并有很好的量效关系。另外,PTH(0.5U、1.0U)明显促进脑突触小体对~(45)Ca的摄取,CT(1.0U、2.0U)则明显抑制~(45)Ca的摄取。结果提示,这两种激素可能通过影响中枢神经细胞Ca~(2+)的摄取,参与中枢的痛觉调节机制。 In this paper, the effects of intraventricular injection of parathyroid hormone (PTH) and calcitonin (CT) on the pain threshold and the uptake of synaptosomal ~ (45) Ca in mice were observed. The results showed that, PTH (0.1U, 0.4U, 0.8U) all reduced the pain threshold in mice, whereas CT (0.5U, 1.0U, 2.0U) increased the pain threshold in mice significantly Good dose-effect relationship. In addition, PTH (0.5 U, 1.0 U) significantly increased the uptake of ~ (45) Ca in brain synaptosomes. CT (1.0 U, 2.0 U) significantly inhibited the uptake of (45) Ca. The results suggest that these two hormones may participate in the central mechanism of pain regulation by affecting Ca 2+ uptake in central nervous system.