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TRAIL能选择性地诱导肿瘤细胞凋亡,而对大多数正常细胞无毒性作用。TRAIL和TRAIL受体生理作用的研究有助于对TRAIL诱导肿瘤细胞凋亡的传导通路的研究。本文综述了近年来TRAIL、TRAIL受体及其凋亡调控途径及TRAIL诱导凋亡的影响因素的研究进展。
TRAIL selectively induces apoptosis in tumor cells and has no toxic effect on most normal cells. Studies on the physiological roles of TRAIL and TRAIL receptors contribute to the study of TRAIL-induced tumor cell apoptosis. This review summarizes the recent progress of the TRAIL, TRAIL receptors and their regulatory pathways and the factors that induce the apoptosis of TRAIL.