多年来,咖啡因与各种剂量的阿司匹林、扑热息痛及水杨酰胺等合并伍用治疗了成千上百万的患者,取得了疗效。但1977年美国食品与药物管理局(FDA)专家委员会在一篇报告中认为:“没有足够的数据证明咖啡因对Ⅰ类止痛剂(即被 FDA 确证为安全有效的止痛剂类)组分有增强作用”。作者为评价咖啡因作为止痛辅助药的效果,对过去20年间包括一万名以上患者的30篇临床研究报告进行了分析。 Over the years, caffeine has been effective in treating millions of patients with various doses of aspirin, paracetamol, and salicylamide. However, in 1977, the FDA Committee of Experts said in a report: “There is not enough data to prove that caffeine is effective against Category I analgesics (ie analgesics that FDA has certified safe and effective) There is enhancement ”. To assess the efficacy of caffeine as a painkiller adjunct, the authors analyzed 30 clinical studies that included more than 10,000 patients in the past 20 years.