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前列腺癌对抗雄性激素治疗的反应好,但是大约30％的病例对激素治疗毫无反应,而在开始治疗后的48个月内死于本病,因此进行了各种化学药物治疗的尝试。 1975年,De Wys,Scott,Tejada,1976年Merrin等的预试治疗结果的论文,环磷酰胺和5-氟尿嘧啶客观缓解的作用是肯定的,以后又有对比较新的药物,如阿霉素,环己亚硝尿,氯乙环己亚硝尿,三嗪咪唑胺和甲基苄肼在治疗中的评价。作者报告了1973—1976年间在Royal Marsden医院使用化学药物治疗晚期前列腺癌的经过。病例选择的主要条件点为经病理证实为前列腺癌,并且以前没有进行过激素以外的化学治疗。17例患者在这项研
Prostate cancer responded well to anti-androgen therapy, but about 30% of cases did not respond to hormonal therapy and died of the disease within 48 months of starting treatment. Therefore, various chemical drug treatments were attempted. In 1975, De Wys, Scott, Tejada, 1976 Merrin et al.’s paper on the results of pre-trial treatment, the role of objective remission of cyclophosphamide and 5-fluorouracil was positive, and later there were newer drugs such as doxorubicin. The evaluation of nitroguanidine in urine, chlorhexidine, urine, triazide imidazole and methylbenzhydramide in treatment. The authors report the use of chemical drugs in the treatment of advanced prostate cancer at the Royal Marsden Hospital between 1973 and 1976. The main condition for case selection is pathologically proven prostate cancer, and no chemotherapy other than hormones has been previously performed. 17 patients in this study