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【目的】评估14 C 尿素呼吸试验 ( 14 C UBT)对幽门螺杆菌 (HP)感染的诊断价值 ,并探讨胃粘膜组织学变化对实验结果的影响。【方法】取 96例因上腹症状行胃镜检查的患者胃窦粘膜活检 ,分别行改良Giemsa染色和快速尿素酶 (RUT)试验 ,14 C UBT检查 ;将三项检查中两项 (或以上 )阳性者定为HP感染 ,分别对三种方法进行评价 ,并且观察其在不同胃粘膜病变中HP检出情况。【结果】14 C UBT的敏感性、特异性、符合率分别为 89.2 % ,98.3 % ,94.8% ,与组织学方法 (改良Giemsa染色为 91.9% ,93 .2 % ,92 .7% ,RUT为86 .5 % ,93 .2 % ,90 .6 % )比较差异无显著性 (均P >0 .0 5 ) ,同时不同胃粘膜病变对14 C UBT结果无明显影响。【结论】14 C UBT有较高的敏感性和特异性 ,是一可靠的非侵入性HP检测方法
【Objective】 To evaluate the diagnostic value of 14 C UBT in diagnosis of Helicobacter pylori (HP) infection and to investigate the influence of gastric mucosal histological changes on the experimental results. 【Methods】 A total of 96 patients with gastroscopy were enrolled in this study. Gastric mucosa biopsy was performed in 96 patients with gastroscopy. Modified Giemsa staining, rapid urease (RUT) test and 14 C UBT were performed respectively. Two (three or more) The positive were identified as HP infection, and the three methods were evaluated respectively, and the detection of HP in different gastric mucosal lesions was observed. 【Results】 The sensitivity, specificity and coincidence rates of 14 C UBT were 89.2%, 98.3% and 94.8%, respectively. Compared with histological methods (modified Giemsa staining 91.9%, 93.2%, 92.7%, RUT was 86.5%, 93.2% and 90.6% respectively) (P> 0.05), meanwhile gastric mucosal lesion had no significant effect on 14 C UBT. 【Conclusion】 14 C UBT has high sensitivity and specificity and is a reliable noninvasive HP detection method