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目的 了解辽宁省正常人群不同年龄组抗麻疹病毒抗体免疫水平。方法 1999年采集全省 6个市地 14个区县不同年龄组 6 93份血清 ,使用B95A细胞以微量细胞培养方法测定抗麻疹病毒中和抗体。结果 2～ 4岁 ,2 0～ 2 5岁组抗体阳性率为 94% ,其它年龄组均在 96 %以上。但是 2～ 4岁GMT开始下降 ,6～ 8、9～ 11岁组最低 ,这两个年龄组发病率也最高。此结果与 1999年麻疹发病率吻合。结论 提示儿童在 2岁和 5岁时应各进行 1次麻疹疫苗接种 ;鉴于 1999年 13～ 15岁组麻疹发病率是 0 6 / 10万的情况 ,建议如果条件允许 ,14岁以下年龄应每隔 5～ 6年普遍再接种 1次麻疹疫苗。
Objective To understand the anti-measles virus antibody levels in different age groups of normal population in Liaoning Province. Methods Six hundred and seventy-three sera of different age groups in 14 districts and counties of 6 cities in the province were collected in 1999. The anti-measles virus neutralizing antibodies were detected by B95A cells in minimal culture. The results of 2 to 4 years old, 20 to 25 years old antibody positive rate was 94%, other age groups were above 96%. However, 2 to 4 years old GMT began to decline, 6 to 8, 9 to 11 years old the lowest, the highest incidence of these two age groups. This result is consistent with the incidence of measles in 1999. The findings suggest that children should receive one measles vaccine at 2 and 5 years of age respectively. Given the incidence of measles in the 13-15 age group in 1999, it is recommended that if the conditions permit, the age of 14 should be Vaccination 1 measles vaccine every 5 to 6 years.