肺癌是呼吸系统最常见的恶性肿瘤,近年来发病率和死亡率明显上升,75年即已占北京市恶性肿瘤之首位、上海市第二位,严重危胁人民的生命健康。目前,肺癌总的五年生存率徘徊在10%上下,但Ⅰ期肺癌术后五年生存率可达80%左右,所以征服肺癌的关键之一是早期诊断。临床上有许多病人虽经各种检查,但术前仍无法明确诊断,尤其是早期诊断更为困难,因此肺癌的诊断方法还需不断完善。近年来,随着免疫学的进展,国外有人发现肺癌患者支气管分泌物中免疫球蛋白A(IgA)明显升高,有助于肺癌的诊断和鉴别诊断。国内还没有人从事此项工作。本文即试图应用免疫酶标法分析各种肺部疾病,特别是肺癌支气管分泌物 IgA 浓度的改变,探讨其临床意义及应用的可能性,并结合支气管镜检查,提高肺癌的早期诊断水平。 Lung cancer is the most common malignant tumor in the respiratory system. In recent years, morbidity and mortality have risen significantly. It has accounted for the first place in malignant tumors in Beijing and the second place in Shanghai in 75 years, seriously threatening people’s lives and health. At present, the overall five-year survival rate of lung cancer remains at or below 10%, but the five-year survival rate of stage I lung cancer can reach 80%. Therefore, one of the keys to conquering lung cancer is early diagnosis. Although many patients in clinical practice have undergone various examinations, they cannot make a diagnosis before surgery. In particular, early diagnosis is more difficult. Therefore, the diagnosis of lung cancer needs to be continuously improved. In recent years, with the development of immunology, it has been found that the immunoglobulin A (IgA) levels in bronchial secretions of patients with lung cancer are significantly increased, which contributes to the diagnosis and differential diagnosis of lung cancer. No one in China has yet engaged in this work. This article attempts to use immuno-enzyme immunoassay to analyze various lung diseases, especially the change of IgA concentration in lung cancer bronchial secretions, to explore its clinical significance and the possibility of application, and combined with bronchoscopy to improve the early diagnosis of lung cancer.