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目的探讨不同时期糖尿病慢性肾脏疾病(CKD)患者血浆心钠素(ANP)水平变化及其临床意义。方法选取T2DM患者93例,根据UAER分为单纯糖尿病(DM)组30例、CKD 3期(CKD3)组31例及CKD 4期(CKD 4)组32例,另选健康体检者30名作为正常对照(NC)组。采用ELISA测定各组血浆ANP水平。结果 (1)DM、CKD 3和CKD 4组ANP水平均高于NC组,且随UAER增加而增加[(280.89±43.66)vs(356.87±45.45)vs(414.95±57.52)vs(164.09±36.64)ng/L,P<0.05];(2)ANP水平与病程、HbA1c、FPG、TG、BUN、Cr呈正相关(r=0.77、0.82、0.73、0.71、0.80、0.74,P均<0.05),与HDL-C呈负相关(r=-0.68,P<0.05)。结论血浆ANP与CKD患者UAER正相关,FPG、HbAc、BUN、Cr和TG是血浆ANP的独立正相关因子。
Objective To investigate the changes of plasma atrial natriuretic peptide (ANP) in patients with chronic kidney disease (CKD) at different stages and its clinical significance. Methods Ninety-three T2DM patients were selected and divided into three groups according to UAER: 30 cases of DM, 31 cases of CKD3 and 32 cases of CKD4, 30 healthy subjects were selected as normal Control (NC) group. Plasma ANP levels were measured by ELISA. Results (1) The levels of ANP in DM, CKD 3 and CKD 4 groups were higher than that in NC group and increased with UAER [(280.89 ± 43.66) vs (356.87 ± 45.45) vs (414.95 ± 57.52) vs (164.09 ± 36.64) ng / L, P <0.05]. (2) There was a positive correlation between the level of ANP and the course of HbA1c, FPG, TG, BUN and Cr (r = 0.77,0.82,0.73,0.71,0.80,0.74, P <0.05) HDL-C was negatively correlated (r = -0.68, P <0.05). Conclusion Plasma ANP is positively correlated with UAER in patients with CKD, and FPG, HbAc, BUN, Cr and TG are independent positive correlations of plasma ANP.