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建立了一种简易可行的测定铜绿假单胞菌对药物外膜通透性的方法，在此基础上，对临床分离的耐β－内酰胺类抗生素（至少耐１种β－内酰胺类抗生素）的铜绿假单胞菌测定了对头孢唑林及亚胺培南／西司他丁的外膜通透性，结果表明：在测试的１０１株菌株中对头孢唑林的通透率为１００％的有７株，占６．９３％；而在测试的３２株菌株中对亚胺培南／西司他丁的通透率为１００％的有７株，占２１．８７％，１０株对头孢唑林敏感的大肠杆菌均显示良好的外膜通透性。并对建立的方法进行了讨论。
A simple and feasible method to determine the permeability of Pseudomonas aeruginosa to drug adventitia was established. On the basis of this, the clinical isolates resistant to β-lactam antibiotics (at least 1 kinds of β-lactam antibiotics ) Of Pseudomonas aeruginosa on cefazolin and imipenem / cilastatin outer membrane permeability, the results showed that: the tested 101 strains of cefazolin on the permeability of 100 7 of 7 strains accounted for 6.93% of the total, while 7 strains of imipenem / cilastatin were 100% permeable in the 32 tested strains (21.87%, 10 strains) Cefazolin sensitive Escherichia coli showed good outer membrane permeability. The method of establishment is discussed.