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柴苓汤临床用于治疗肾病综合征及肾小球肾炎,本次对柴苓汤能否增强环孢菌素A(CyA)治疗肾病的疗效进行了探讨。 材料和方法:选用SD系雄性大鼠,单次静脉给予氨基核苷嘌呤霉素(PAN)100mg/kg制作肾病模型,对照组给予生理盐水。造模1d后即开始经口给予柴苓汤(1.0g/kg),造模6d后口服CyA(10、20、40mg/kg)。根据造模后6、11、15d尿蛋白排泄量及造模后15d血中总胆固醇、甘油三酯和白蛋白水平判断肾脏病变程度。
Chaiqin Decoction is used to treat nephrotic syndrome and glomerulonephritis. The effect of Chaiqin Decoction on enhancing the efficacy of Cyclosporin A (CyA) in the treatment of nephropathy is discussed. Materials and Methods: Male SD rats were selected and a single dose of aminoguanine puromycin (PAN) 100 mg/kg was used to make a kidney model. The control group was given saline. One day after modeling, oral administration of Chaiqin Decoction (1.0g/kg) was started, and CyA (10, 20, 40mg/kg) was given orally after 6 days. According to the urinary protein excretion at the 6th, 11th, and 15th days after modeling and the blood total cholesterol, triglyceride and albumin levels at 15 days after modeling, the degree of renal disease was judged.