本文通过比较国产复方非洛地平缓释片试验制剂与同时服用非洛地平片和马来酸依那普利片两种参比制剂的药代动力学特征,采用开放、随机、自身交叉试验设计,筛选12位健康男性受试者,随机分为2组,每组6人,周期间的洗脱期为14天。我们发现与普通片剂相比,复方非洛地平缓释片中非洛地平成分具有明显的缓释特征,而另一成分依那普利及其活性代谢产物依那普利拉则无缓释效果。 In this paper, by comparing the pharmacokinetics of the two formulations of felodipine and enalapril maleate, the domestic compound felodipine sustained-release tablets test preparation and the open-label randomized crossover design , 12 healthy male subjects were screened and randomly divided into 2 groups with 6 in each group. The period of elution was 14 days. We found that compared with conventional tablets, the compound felodipine sustained-release tablets felodipine ingredient has a sustained release characteristics, and the other component of enalapril and its active metabolite enalapril no is slow Release effect.