论文部分内容阅读
目的报道1例伴横纹肌样特征的肺癌,并复习相关文献。方法石蜡包埋组织连续切片分别做HE染色、Alcianblue黏液组化染色和免疫组化染色,光镜观察。结果肿瘤突出于右上肺支气管腔,HE染色显示在差分化癌组织中可见横纹肌样特征的癌细胞,约占30%,其细胞质丰富,细胞质内可见明显的嗜酸性包涵体,细胞核偏位,可见核仁。癌组织黏液染色阴性。免疫组化染色显示,vimentin和p63呈弥漫性强阳性,CKpan、CAM5·2、TTF-1和synaptophysin呈灶性阳性,嗜酸性包涵体对CAM5·2呈阳性反应,CEA、chromograninA、SCLC、myoglobin及desmin阴性。结论伴横纹肌样特征的肺癌是原发性肺癌少见的特殊亚型,可存在于差分化非小细胞肺癌中,并可显示灶性神经内分泌分化。
Objective To report a case of lung cancer with rhabdomyosarcoma and review the related literature. Methods Serial sections of paraffin embedded tissue were stained with HE, Alcianblue mucosa and immunohistochemistry respectively, and observed with light microscope. Results The tumor was prominent in the bronchus of the right upper lung. Hematoxylin and eosin staining showed that there were about 30% of rhabdomyosarcoma cells differentiated in cancerous tissues. The cytoplasm was rich in cytoplasm, and obvious eosinophilic inclusion bodies were observed in the cytoplasm. Nucleolus. Mucinous tissue stain negative. Immunohistochemical staining showed that vimentin and p63 were diffuse strongly positive, CKpan, CAM5 · 2, TTF-1 and synaptophysin were focal positive, eosinophilic inclusion bodies positive for CAM5 · 2, CEA, chromograninA, SCLC, myoglobin And desmin negative. Conclusions Pulmonary cancer with rhabdomyosarcoma is a rare subtype of primary lung cancer that may be present in differentiated non-small cell lung cancer and may show focal neuroendocrine differentiation.