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目的探讨幽门螺杆菌(HP)所致消化性溃疡复发根治效果,寻求疗效好且安全、方便、价格合理的治疗方案。方法A组(n=27)采用奥美拉唑、甲硝唑、果胶铋三联疗法;B组(n=27)采用兰索拉唑、甲硝唑、克拉霉素、果胶铋四联疗法,进行1～2周治疗。结果两周后两组HP根除率、溃疡愈合情况、主要症状都有显著改善,疗效相当,三联疗法的不良反应与四联疗法相比,差异无统计学意义。结论奥美拉唑、甲硝唑、果胶铋三联疗法与目前推崇的兰索拉唑、甲硝唑、克拉霉素、果胶铋四联疗法相比,其HP根除率、溃疡愈合率、症状消失等均疗效相当,但相比价格便宜,患者依从性好,不良反应少,耐受性好,溃疡愈合迅速,症状消失快,值得基层医院推广应用。
Objective To investigate the curative effect of peptic ulcer recurrence caused by Helicobacter pylori (HP) and to seek a safe, convenient and affordable treatment plan. Method A (n = 27) was treated with omeprazole, metronidazole and pectin bismuth triple therapy. Group B (n = 27) was treated with lansoprazole, metronidazole, clarithromycin, Therapy, for 1 to 2 weeks treatment. Results Two weeks after the two groups of HP eradication rate, ulcer healing, the main symptoms have significantly improved, the effect is equivalent, triple therapy adverse reactions and quadruple therapy, the difference was not statistically significant. Conclusion Omeprazole, metronidazole, pectin bismuth triple therapy and currently respected lansoprazole, metronidazole, clarithromycin, bismuth pectate quadruple therapy, the HP eradication rate, ulcer healing rate, Symptoms disappear, etc. are quite effective, but compared to cheap, good patient compliance, fewer adverse reactions, good tolerance, rapid healing of ulcers, symptoms disappear quickly, it is worth promoting the use of primary hospitals.