论文部分内容阅读
目的:探讨慢性B淋巴细胞白血病(B-CLL)患者ZAP-70、CD38的表达与中医辨证分型的关系。方法:采用流式细胞术检测对40例B-CLL病人骨髓或外周血ZAP-70、CD38的表达水平,并从分子生物学角度探讨其与中医证型的关系。结果:气阴两虚型患者ZAP-70、CD38的表达率明显高于淤血痰结型(P<0.05)。结论:ZAP-70、CD38的表达为指导CLL中医辨证诊治提供了客观指标。
Objective: To investigate the relationship between the expression of ZAP-70 and CD38 in patients with chronic lymphocytic leukemia (B-CLL) and the syndrome differentiation of traditional Chinese medicine. Methods: Flow cytometry was used to detect the expression of ZAP-70 and CD38 in bone marrow or peripheral blood of 40 patients with B-CLL. The relationship between the expression of ZAP-70 and CD38 was also observed in molecular biology. Results: The expression rates of ZAP-70 and CD38 in patients with deficiency of both qi and yin were significantly higher than those in patients with congestion and sputum (P <0.05). Conclusion: The expression of ZAP-70 and CD38 provides an objective index to guide TCM diagnosis and treatment of CLL.