胆囊癌是一种少见的恶性肿瘤,很少能作出早期诊断,且予后不良。作者报告3例患者,对其高触珠蛋白血症(>700mg/dl)和晚期胆囊癌的联系作了研究。患者均为女性,年龄为51、66、69岁。典型病例如下:女性,69岁,主诉腹痛和中上腹饱满感。体检显示右上腹压痛,肝触诊胸骨下4cm,由于口服和静注胆囊造影剂胆囊不显影,拟诊为急性胆囊炎并施行剖腹探查术。手术时发现中度分化的胆囊腺癌且扩展到肝脏。因该病发展,未做根除术。术后二周用放射免疫扩散法测定血清触珠蛋白为830mg/dl(正常50～220mg/dl),随后对肿瘤部位进行放疗,每周静脉注射5氟脲嘧啶400mg,但治疗无效。术后15周,终因癌肿弥漫性 Gallbladder cancer is a rare malignancy, and it can rarely be diagnosed early and it can be worse afterwards. The authors report the association of high haptoglobinemia (>700 mg/dl) and advanced gallbladder cancer in 3 patients. All patients were female, aged 51, 66, and 69 years old. Typical cases are as follows: Female, 69 years old, complains of abdominal pain and fullness in the mid-upper quadrant. Physical examination showed tenderness in the right upper quadrant, hepatic palpation of 4 cm below the sternum, and the gallbladder was not developed due to oral and intravenous injection of cholecystograms. He was diagnosed as acute cholecystitis and underwent laparotomy. A moderately differentiated gallbladder adenocarcinoma was found during surgery and spread to the liver. Due to the development of the disease, no eradication was performed. Two weeks after the operation, serum haptoglobin was determined to be 830 mg/dl by radioimmuno-diffusion (normally 50 to 220 mg/dl). Radiotherapy was then performed on the tumor site and intravenous fluorouracil 400 mg was administered intravenously every week. However, the treatment was ineffective. 15 weeks after surgery, due to diffuse cancer