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目的 探讨男性乳腺癌的生物学特性与预后的关系。方法 回顾1970年至1998年13例男性乳腺癌病例,从肿块大小、组织分型、淋巴转移及激素受体加以研究分析。结果 TNM分期Ⅰ期2例,Ⅱ期7例,Ⅲ期3例,Ⅳ期1例。7例病人行乳癌根治术,5例病人行改良根治术,1例病人行肿块切除术及睾丸切除术。术后病理提示10例患者(76.9％)腋淋巴结阳性。雌激素受体(ER)阳性及孕激素阳性(PR)分别为76.9％及53.8％。病理类型主要为导管浸润癌(84.6％)。5年和10年生存率分别为69.2％和53.8％。结论 男性乳腺癌的早期诊断是取得良好预后的关键。
Objective To investigate the relationship between biological characteristics and prognosis of male breast cancer. Methods Thirteen cases of male breast cancer from 1970 to 1998 were retrospectively analyzed, including tumor size, histological type, lymph node metastasis and hormone receptor. Results TNM stage Ⅰ in 2 cases, stage Ⅱ in 7 cases, stage Ⅲ in 3 cases, stage Ⅳ in 1 case. Seven patients underwent radical mastectomy, five patients underwent modified radical mastectomy, and one patient underwent lumpectomy and orchiectomy. Postoperative pathology showed that 10 patients (76.9%) were axillary lymph nodes. Estrogen receptor (ER) positive and progesterone positive (PR) were 76.9% and 53.8% respectively. The main pathological type was ductal carcinoma (84.6%). The 5-year and 10-year survival rates were 69.2% and 53.8% respectively. Conclusion The early diagnosis of male breast cancer is the key to good prognosis.